The Hx338 sensor provides biotechnology and pharmaceutical processes with the unique Tri-Triple reference technology. The Tri-Triple reference is made up of three (3) separate peripheral liquid junctions that make contact with the solution, and then two (2) inner junctions that protect the reference. The first junction eliminates flow sensitivity and maintains a steady reference signal. The three overall reference junctions work together to help maintain a drift-free pH signal and fight poisoning ions (i.e. sulfides, proteins, or sugars), even after numerous sterilization cycles.